It's hard to make luggage sexy, but Rimowa's Pilot Case fits the bill.

"The top opening provides easy access to your belongings, and the padded laptop pouch can be removed to transform the business case into a versatile toolbox. Multiple pockets of different sizes keep essentials organized, including two zipped pockets intended to hold batteries and chargers, and a vertical pocket designed to hold a small water bottle or umbrella."

The supreme irony is that after ponying up $1,550 for one of these, you may not be flying with it, at least commercial; the case's quirky dimensions—19.69" x 16.54" x 9.06"—don't quite jive with the 22" x 14" x 9" cage that the gate attendant occasionally demands you stuff it into. But maybe you'll get lucky. Or, you could just live up to the bag's name and become a pilot; they've got more luggage leeway.